Publications - Duronio Lab

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Nevil M, Duronio RJ. The awesome power of histone genetics. Mol Cell. 2021 Apr 15;81(8):1593-1595. doi: 10.1016/j.molcel.2021.03.023.
Armstrong RL, Duronio RJ. Phasing in heterochromatin during development. Genes Dev. 2019 Apr 1;33(7-8):379-381. doi: 10.1101/gad.324731.119.
Abdullah C, Duronio RJ. The many fates of tissue regeneration. PLoS Genet. 2018 Nov 21;14(11):e1007728. doi: 10.1371/journal.pgen.1007728. eCollection 2018 Nov.
Duronio R.J., Marzluff W.F. Coordinating cell cycle-regulated histone gene expression through assembly and function of the Histone Locus Body. RNA Biol. 2017 Jun 3;14(6):726-738. doi: 10.1080/15476286.2016.1265198. Epub 2017 Jan 6 (2017).
Marzluff, W.F., Duronio, R.J. Genome stress response in early development. Dev. Cell, 29 (4):375-6 (2014).
Fox, D.T. and Duronio, R.J. Endoreplication and polyploidy: recent insights into development and disease. Development, 140:3-12 (2013).
Meserve, J.H. and Duronio, R.J. Atypical E2Fs drive atypical cell cycles. Nature Cell Biology, 14, 1124-1125 (2012).
Duronio, R.J. Developing S-phase control. Genes & Dev. 26, 746-750 (2012).
Swanson, C.I., and Duronio, R.J. Developmental regulation of replication-coupled protein destruction. Cell Cycle 10, 859-860 (2011).
Lee, H.O., Davidson, J.M., and Duronio, R.J. Endoreplication: polyploidy with purpose. Genes & Dev. 23, 2461–2477 (2009).
Marzluff, W.F., Wagner, E.J., and Duronio, R.J. Metabolism and regulation of histone mRNAs: life without a polyA tail. Nat. Rev. Genetics 9, 843-854 (2008).
Lilly, M.A. and Duronio, R.J. New insights into cell cycle control from the Drosophila endocycle. Oncogene. 24, 2765-2775 (2005).
Swanhart, L., Kupsco, J., and Duronio, R.J. Developmental Control of Growth and Cell Cycle Progression in Drosophila. Methods Mol Biol. 296, 69-94 (2005).
Donaldson, T.D. and Duronio, R.J. Cancer cell biology: Myc wins the competition. Curr. Biol. 14, R425-427 (2004).
Duronio, R.J. A Breath of Fresh Air for Cyclin D/Cdk4; Triggering Growth via Hph. Dev. Cell. 6, 163-164 (2004).
Cayirlioglu, P. and Duronio, R.J. Cell Cycle: Flies teach an old dogma new tricks. Curr. Biol., 11, R178-R181 (2001).
Myster, D.L. and Duronio, R.J., Cell cycle: To differentiate or not to differentiate. Curr. Biol., 10, R302-R304 (2000).

Meserve JH, Duronio RJ. Fate mapping during regeneration: Cells that undergo compensatory proliferation in damaged Drosophila eye imaginal discs differentiate into multiple retinal accessory cell types. Dev Biol. 2018 Dec 15;444(2):43-49. doi: 10.1016/j.ydbio.2018.10.011. Epub 2018 Oct 19.
Meserve J.H., Duronio R.J. A population of G2-arrested cells are selected as sensory organ precursors for the interommatidial bristles of the Drosophila eye. Dev Biol. 2017 Jun 21. pii: S0012-1606(16)30868-5. doi: 10.1016/j.ydbio.2017.06.023. [Epub ahead of print] (2017).
Swanson C.I., Meserve J.H., McCarter P.C., Thieme A., Mathew T., Elston T.C., Duronio R.J. Expression of an S phase-stabilized version of the CDK inhibitor Dacapo can alter endoreplication. Development. 2015 Dec 15;142(24):4288-98. doi: 10.1242/dev.115006. Epub 2015 Oct 22 (2015).
Meserve J.H., Duronio R.J. Scalloped and Yorkie are required for cell cycle re-entry of quiescent cells after tissue damage. Development 2015 142: 2740-2751; doi: 10.1242/dev.119339 (2015).
Davidson, J.M. and Duronio, R J. S Phase-coupled E2f1 Destruction Ensures Homeostasis in Proliferating Tissues. PLoS Genetics 8:e1002831 (2012).
Zielke, N., Kim, K.J., Tran, V., Shibutani, S.T., Bravo, M.J., Nagarajan, S., van Straaten, M., Woods, B., von Dassow, G., Rottig, C., Lehner, C.F., Grewal, S.S., Duronio, R.J., and Edgar, B.A. Control of Drosophila endocycles by E2F and CRL4^CDT2. Nature 480:123-127 (2011).
Lee, H.O., Zacharek, S., Xiong, Y., and Duronio, R.J. Cell type-dependent requirement for PIP box-regulated Cdt1 destruction during S phase. Mol. Biol. Cell 21, 3639-3653 (2010).
Shibutani, S.T., de la Cruz, A.F. A., Turbyfill III, W.J., Tran, V., Reis, T., Edgar, B.A., and Duronio, R.J. Intrinsic negative cell cycle regulation provided by PIP box- and Cul4^Cdt2-mediated destruction of E2f1 during S phase. Dev. Cell 15, 890-900 (2008).
Reynolds, P.J., Simms, J.R., and Duronio, R.J. Identifying Determinants of Cullin Binding Specificity Among the Three Functionally Different Drosophila melanogaster Roc Proteins via Domain Swapping. PLoS ONE 3, e2918 (2008).
Hall, J.R., Lee, H.O., Bunker, B.D., Dorn, E.S., Rogers, G.C., Duronio, R.J., Cook, J.C. CDT1 and CDC6 are destabilized by re-replication-induced DNA damage. J. Biol. Chem. 283, 25356-25363 (2008).
Hu, J., Zacharek, S., He, Y.J., Lee, H., Shumway, S. Duronio, R.J., and Xiong, Y. WD40 protein FBW5 promotes ubiquitination of tumor suppressor TSC2 by DDB1-CUL4-ROC1 ligase. Genes & Dev., 22, 866-871 (2008).
Swanhart, L.A., Sanders, A.N., and Duronio, R.J., Normal regulation of Rbf1/E2f1 target genes in Drosophila Type 1 protein phosphatase mutants. Dev. Dyn., 236, 2567-2577 (2007).
Shibutani, S., Swanhart, L.M., and Duronio, R.J. Rbf1-independent termination of E2f1 target gene expression during early Drosophila embryogenesis. Development, 134, 467-478 (2007).
Donaldson, T.D., Noureddine, M.A., Reynolds, P.J., Bradford, W., and Duronio, R.J. Targeted disruption of Drosophila Roc1b reveals functional differences in the Roc subunit of Cullin-dependent E3 Ubiquitin Ligases. Mol. Biol Cell 15, 4892–4903 (2004).
Cayirlioglu, P. Ward, W.O., Silver Key, S.C., and Duronio, R.J. Transcriptional repressor functions of Drosophila E2F1 and E2F2 cooperate to inhibit genomic DNA synthesis in ovarian follicle cells. Mol. Cell. Biol. 23, 2123-2134 (2003).
Thacker, S.A., Bonnette, P.C., and Duronio, R.J. The contribution of E2F-regulated transcription to Drosophila PCNA function. Curr. Biol. 13, 53-58 (2003).
Noureddine, M.A., Donaldson,T.D., Thacker, S.A., and Duronio, R.J. Drosophila Roc1a encodes a RING-H2 protein with a unique function in processing the Hh signal transducer Ci by the SCF E3 ubiquitin ligase. Dev. Cell 2, 757-770 (2002).
Cayirlioglu, P., Bonnette, P.C., Dickson, M.R., and Duronio, R.J. Drosophila dE2F2 Promotes the Conversion from Genomic DNA Replication to Gene Amplification in Ovarian Follicle Cells. Development, 128, 5085-5098 (2001).
Myster, D.L., Bonnette, P.C., and Duronio, R.J. A role for the DP subunit of the E2F transcription factor in axis determination during Drosophila oogenesis. Development, 127, 3249-3261 (2000).

Kemp JP Jr, Yang XC, Dominski Z, Marzluff WF, Duronio RJ. Superresolution light microscopy of the Drosophila histone locus body reveals a core-shell organization associated with expression of replication-dependent histone genes. Mol Biol Cell. 2021 Apr 19;32(9):942-955. doi: 10.1091/mbc.E20-10-0645. Epub 2021 Mar 31.
Hur W., Kemp J.P., Tarzia M., Deneke V.E., Marzluff W.F., Duronio R.J.,Di Talia S. CDK-Regulated Phase Separation Seeded by Histone Genes Ensures Precise Growth and Function of Histone Locus Bodies. Dev. Cell 54, 1–16 (2020).
Koreski K.P., Rieder L.E., McLain L.M., Chaubal A., Marzluff W.F., Duronio R.J. Drosophila histone locus body assembly and function involves multiple interactions. Mol. Biol. Cell 31, 1437-1549 (2020).
Rieder L.E., Koreski K.P., Boltz K.A., Kuzu G., Urban J.A., Bowman S.K., Zeidman A., Jordan W.T. 3rd, Tolstorukov M.Y., Marzluff W.F., Duronio R.J., Larschan E.N. Histone locus regulation by the Drosophila dosage compensation adaptor protein CLAMP. Genes Dev. 2017 Jul 15;31(14):1494-1508. doi: 10.1101/gad.300855.117. Epub 2017 Aug 24 (2017).
Tatomer D.C., Terzo E., Curry K.P., Salzler H., Sabath I., Zapotoczny G., McKay D.J., Dominski Z., Marzluff W.F., Duronio R.J. Concentrating pre-mRNA processing factors in the histone locus body facilitates efficient histone mRNA biogenesis. J Cell Biol. 2016 Jun 6;213(5):557-70. doi: 10.1083/jcb.201504043. Epub 2016 May 30 (2016).
Welch J.D., Slevin M.K., Tatomer D.C., Duronio R.J., Prins J.F., Marzluff W.F. EnD-Seq and AppEnD: sequencing 3′ ends to identify nontemplated tails and degradation intermediates. RNA. 2015 Jul;21(7):1375-89. doi: 10.1261/rna.048785.114. Epub 2015 May 26 (2015).
Terzo E.A., Lyons S.M., Poulton J.S., Temple B.R., Marzluff W.F., Duronio R.J. Distinct self-interaction domains promote Multi Sex Combs accumulation in and formation of the Drosophila histone locus body. Mol Biol Cell. 2015 Apr 15;26(8):1559-74. doi: 10.1091/mbc.E14-10-1445. Epub 2015 Feb 18. Erratum in: Mol Biol Cell. 2015 Jul 1;26(13):2574 (2015).
Tatomer D.C., Rizzardi L.F., Curry K.P., Witkowski A.M., Marzluff W.F., Duronio R.J. Drosophila Symplekin localizes dynamically to the histone locus body and tricellular junctions. Nucleus, 5(6):613-25 (2014).
Salzler, H.R., Tatomer, D.C., Malek, P.Y., McDaniel, S.L., Orlando, A.N., Marzluff, W.F., and Duronio, R. J. A sequence in the Drosophila H3-H4 promoter triggers Histone Locus Body assembly and biosynthesis of replication-coupled histone mRNAs. Dev. Cell 24:623-34 (2013).
Burch, B.D., Godfrey, A.C., Gasdaska, P.Y., Salzler, H.R., Duronio, R.J., Marzluff, W.F., and Dominski, Z. The interaction between FLASH and Lsm11 is essential for histone pre-mRNA processing in vivo in Drosophila. RNA 17, 1132-1147 (2011).
White, A.E., Burch, B.D., Yang, X.C., Gasdaska, P.Y., Dominski, Z., Marzluff, W.F., and Duronio, R.J. Drosophila histone locus bodies form by hierarchical recruitment of components. J. Cell Biol. 193:677-694 (2011).
Salzler, H.R., Davidson, J.M., Montgomery, N.D., and Duronio, R.J. Loss of the Histone pre-mRNA Processing Factor Stem-loop Binding Protein in Drosophila Causes Genomic Instability and Impaired Cellular Proliferation. PLoS ONE 4, e8168 (2009).
Godfrey, A.C., White, A.E., Tatomer, D.C., Marzluff, W.F., and Duronio, R.J. The Drosophila U7 snRNP Proteins Lsm10 and Lsm11 are Required for Histone pre-mRNA Processing and Play an Essential Role in Development. RNA 15, 1661-1672 (2009).
White, A.E., Leslie, M.E., Calvi, B.R., Marzluff, W.F., and Duronio, R.J. Developmental and cell cycle regulation of the Drosophila histone locus body. Mol. Biol. Cell 18, 2491-2502 (2007).
Wagner, E.J., Burch, B.D., Godfrey, A.C., Salzler, H., Duronio, R.J., and Marzluff, W.F. A genome-wide RNA interference screen reveals that variant histones are necessary for replication-dependent histone pre-mRNA processing. Mol. Cell, 28, 692-699 (2007).
Godfrey, A.C., Kupsco, J.M., Burch, B.D., Zimmerman, R.M., Dominski, Z., Marzluff, W.F., and Duronio, R.J. U7 snRNA mutations in Drosophila block histone pre-mRNA processing and disrupt oogenesis. RNA 12, 396-409 (2006).
Kupsco, J.M., Wu, M.J., Marzluff, W.F., Thapar, R., and Duronio, R.J. Genetic and biochemical characterization of Drosophila Snipper:a promiscuous member of the metazoan 3’hExo/Eri1 family of 3’ to 5’ exonucleases. RNA, 12, 2103-2117 (2006).
Lanzotti, D.J., Kupsco, J.M., Marzluff, W.F., and Duronio, R.J. string^cdc25 and cyclin E are required for patterned histone expression at different stages of Drosophila embryonic development. Dev. Biol. 274, 82-93 (2004).
Lanzotti, D.J., Kupsco, J.M., Yang, X.C., Dominski, Z., Marzluff, W.F., and Duronio, R.J. Drosophila SLBP intracellular localization is mediated by phosphorylation and is required for cell cycle-regulated histone mRNA expression. Mol. Biol. Cell 15, 1112-1123 (2004).
Lanzotti, D.A., Kaygun, H., Yang, X., and Duronio, R.J., and Marzluff, W.F. Developmental control of histone mRNA and dSLBP synthesis during Drosophila embryogenesis and the role of dSLBP in histone mRNA 3′ end processing in vivo. Mol. Cell. Biol., 22, 2267-2282 (2002).
Sullivan, E., Santiago, C., Parker, E.D., Dominski, Z., Yang, X., Lanzotti, D.J., Ingledue, T.C., Marzluff, W.F., and Duronio, R.J. Drosophila stem loop binding protein coordinates accumulation of mature histone mRNA with cell cycle progression. Genes & Dev., 15, 173-187 (2001).

Crain, A. T., Klusza, S., Armstrong, R. L., Santa Rosa, P., Temple, B. R. S., Strahl, B. D., … Duronio, R. J. (2022). Distinct developmental phenotypes result from mutation of Set8/KMT5A and histone H4 lysine 20 in Drosophila melanogaster. Genetics, 221(April).
Armstrong RL, Penke TJR, Chao SK, Gentile GM, Strahl BD, Matera AG, McKay DJ, Duronio RJ. H3K9 Promotes Under-Replication of Pericentromeric Heterochromatin in Drosophila Salivary Gland Polytene Chromosomes. Genes (Basel). 2019 Jan 29;10(2). pii: E93. doi: 10.3390/genes10020093.
Armstrong RL, Penke TJR, Strahl BD, Matera AG, McKay DJ, MacAlpine DM, Duronio RJ. Chromatin conformation and transcriptional activity are permissive regulators of DNA replication initiation in Drosophila. Genome Res. 2018 Nov;28(11):1688-1700. doi: 10.1101/gr.239913.118. Epub 2018 Oct 2.
Taylor J. R. Penke, Daniel J. McKay, Brian D. Strahl, A. Gregory Matera, Robert J. Duronio Functional Redundancy of Variant and Canonical Histone H3 Lysine 9 Modification in Drosophila. Genetics, Vol. 208, 229–244 January 2018.
Meers M.P., Henriques T., Lavender C.A., McKay D.J., Strahl B.D., Duronio R.J., Adelman K., Matera A.G. Histone gene replacement reveals a post-transcriptional role for H3K36 in maintaining metazoan transcriptome fidelity. Elife. 2017 Mar 27;6. pii: e23249. doi: 10.7554/eLife.23249 (2017).
Li Y., Armstrong R.L., Duronio R.J., MacAlpine D.M. Methylation of histone H4 lysine 20 by PR-Set7 ensures the integrity of late replicating sequence domains in Drosophila. Nucleic Acids Res. 2016 Apr 29. pii: gkw333. [Epub ahead of print] (2016).
Penke T.J., McKay D.J., Strahl B.D., Matera A.G., Duronio R.J. Direct interrogation of the role of H3K9 in metazoan heterochromatin function. Genes Dev. 2016 Aug 26. [Epub ahead of print] (2016).
McKay D.J., Klusza S., Penke T.J., Meers M.P., Curry K.P., McDaniel S.L., Malek P.Y., Cooper S.W., Tatomer D.C., Lieb J.D., Strahl B.D., Duronio R.J., Matera A.G. Interrogating the function of metazoan histones using engineered gene clusters. Dev Cell. 2015 Feb 9;32(3):373-86. doi: 10.1016/j.devcel.2014.12.025. (2015).